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SO supervised the local implementation of the study design.
KvO and NS contributed to the implementation of the study design into the current state of the trial.
Lessons from the implementation of the study design would also pave way for more holistic research of chronic diseases in health care systems using this methodology.
We experienced some specific unforeseen problems in the implementation of the study design that we were able to solve in a pragmatic way.
In this article we describe challenges that emerged during the implementation of the study design and discuss resolutions strategies to help overcome them.
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KK: conception and initiation of the study, design, implementation of the study and co-writing.
DM: initiation of the study, design, implementation, analysis and writing.
GFK supervised all aspects of the study design, implementation, data analysis and drafting of the manuscript.
FA: conception and initiation of the study, design, implementation, analysis and drafting the manuscript.
KK: conception and initiation of the study, design, implementation, analysis and writing.
TT: initiation of the study, design, implementation, analysis and co-writing.
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