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We describe the implementation of the sequencing protocol in more depth in Discussion. Figure 1 illustrates the sequencing protocol.
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Just as recursive lists provide a simple implementation of the sequence abstraction, streams provide a simple, functional, recursive data structure that implements lazy evaluation through the use of higher-order functions.
However, the concrete implementation of the sequence mining algorithm can be replaced with no impact in the prototype.
SF contributed the idea of sequence-based signatures to this study, developed the concept and implementation of the sequence analyses and helped to draft the manuscript.
A local Java implementation of the "sequence logo" algorithm [ 24] was used to generate a graphic representing the Cre recombinase binding site profile.
As detailed in the Implementation section, the pipeline workflow follows a state-of-the-art implementation of the exome sequencing analysis [ 50] (Additional file 1).
Consider this recursive implementation of the Fibonacci sequence.
The implementation of the ADNI MRI sequence has enabled the pooling of imaging data across sites, and the completion of an imaging study of Alzheimer׳s disease on a much larger scale (Schuff et al., 2009) than would have been possible at a single centre.
Although the implementation of the different sequence property evaluators is usually self-contained within D-Tailor, the computation of specific properties may rely on third party softwares [e.g. UNAfold (Markham and Zuker, 2008) for the prediction of RNA secondary structure].
Consequently, this leads to long acquisition times in the standard implementation of these sequences [ 17].
LZ was involved in the review of data, supervising implementation of the overall process, sequencing, and editing the manuscript.
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