Additional file 1 Provides an implementation of the weighted quantile normalization algorithm (as describe in the " Weighted quantile normalization " section) written for the R language [ 25 ], with a demonstration using simulated data.
However, specific processes are included in our implementation, like the normalization of the score size and the local correction of rotation.
Notice that because of the accumulation of the floating-point error in the implementation of the incremental z-score normalization, (mu _{mathrm{new}}) and (x^2_{mathrm{new}}) will be completely calculated by Eqs.
We developed Hi-Corrector, an easy-to-use, open source implementation of the Hi-C data normalization algorithm.
The main differences between these two programs are the implementation of exon length normalization (SubdivideGRange method) in ExomeCopy [ 13] and generation of aggregate reference set (select.reference.set method) in ExomeDepth [ 14].
In our implementation, the normalization is done locally, in sections of 100 k.
The case study findings indicated that social capital characterized by membership in local groups and associations may have contributed to successful implementation of the intervention and ending open defecation, through normalization and monitoring of the use of ecological sanitation systems.
As EU finance ministers stated last week: [Serbia's] continued visible and sustainable progress in the normalization of relations, including the implementation of the agreements reached so far, remains essential so Kosovo and Serbia can continue on their respective European paths.
Due to current trends in legislation and normalization in the context of implementation of the Water Framework Directive, their use will probably increase in the future.
The normalization process model assisted in categorising the challenges experienced during implementation of the intervention.
