Existing reports on prototyping projects merely present their methodological set-up and results, but lack description of the implementation of the methodology.
Although the number of economic evaluations of pharmacoeconomic guidelines has increased, the use of economic evaluations in other jurisdictions usually requires the implementation of methodological adaptations for the specific environment under investigation [ 2, 3].
Additionally, the implementation of new methodological platforms such as metabolic engineering and systems biology have facilitated the controlled production of natural nanoparticles produced by bacteria, including metallic deposits of Au, Ag, Cd, Zn or Fe, virus-like particles or other nanoscale protein-only entities.
Additionally, the implementation of new methodological platforms regarding production of endotoxin free PHA nanobeads using Gram-positive bacteria opened new avenues for biomedical applications.
In this article, we present the key functionalities of the toolbox, quantify their performance, and discuss the novel implementation of important methodological concepts concerning parameter identifiability, confidence intervals and statistical tests for model validation and discrimination.
As shown in a descriptive literature analysis of the methodological implementation of overviews, many authors used the GRADE approach to evaluate the quality of evidence [ 68].
Development and roll out: The programme's activities have focused on: 1) development of the SIC; 2) capacity-building of communal committees in charge of the implementation of the planning process; and 3) methodological and technical support to communities via external experts from the National Coordinating Committee of the Programme.
We also highlight the lack of significant association between citation frequency and model complexity, model performance, implementation of conventional methodological steps during model development (e.g., validation, sensitivity analysis), number of authors, and country of affiliation.
Details of the methodological design and implementation of individual evaluations can be found in each of the nine sections of the report.
