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As well as the implementation of such a paradigm, a method for the interaction between models is in particular developed to achieve high accuracy for the simulation of design problems involving the solving of system equations.
The following section discusses the kinds of tools and associated resources needed to support workplace implementation of such a paradigm.
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Early signs of such a paradigm shift already exist.
At best, we might be at the very beginning of such a paradigm shift.
The advantages of such a paradigm were recently reviewed by Lu & Dosher [26].
Through the lens of such a paradigm, more practice is not necessarily better.
The application of such a paradigm in cachectic cancer patients would therefore warrant investigation.
Implementation of such a strategy could foster a new paradigm that enhances human relevance of toxicological studies, thereby allowing regulatory decisions to be based on human rather than animal biology (Hartung 2009; Schmidt 2009).
Still, full-scale implementation of such a service is a future perspective.
Implementation of such a scheme would require the co-operation of corporations and governments.
Implementation of such a unit in EDs varies by country.
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