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Overall positivity may be as low as 30-40% despite proper implementation of standard procedures, adequate blood volume collection and a high clinical suspicion of BSI.
The positive predictive value of cultures is estimated to be above 95% but in BSI the overall positivity may be as low as 30 to 40% despite proper implementation of standard procedures, adequate blood volume collection and substantial clinical suspicion of BSI [ 16- 18].
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Interventions mainly consisted of individual teachings on work performance with direct feedbacks (1h/ day during the intervention phases), development and implementation of standard operation procedures (SOPs), and the compilation of flowcharts for patient admission.
The institution of an interactive consortium for a globalized biorepository, high throughput and multidimensional technologies, sophisticated experimental and clinical study design, strong bioinformatics approaches, and harmonization of studies through the implementation of standard operative procedures with voluntary participation might provide cost-effective solutions.
Structural changes and further implementation of standard operating procedures might achieve this.
They recommended implementation of standard operating procedures, security measures and increases in the quantity and quality of stress relief courses [ 18].
These results guided the development and implementation of standard operating procedures as well as increased involvement of the policy review unit in subsequent policy formulation and review processes [ 12].
Interventions that could improve the likelihood of TB diagnosis at health facilities may include implementation of standard screening procedures, additional training of health care workers, education of patients (so that they expect and request diagnostic testing for TB when appropriate), and better access to and reduced costs for diagnostic tests.
Interventions like the implementation of standard screening procedures and rapid diagnostics, training and close supervision of health care providers, strengthening quality control and education of patients so that they expect and request diagnostic testing for TB when appropriate, and reduced costs for diagnostic tests could improve the likelihood of TB diagnosis at health facilities.
The development of each of these global high-throughput technologies has triggered implementation of standard operating procedures, ontologies and quality-assurance pipelines for data collection and analysis using dedicated software and databases, and this has required a change in culture in biological laboratories [ 77- 81].
Therefore, education, training, the strict application of standard/universal procedures (protective gown, gloves, mask, glasses, etc)., and also the implementation of local standardized procedures are of paramount importance.
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