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This study fills an important gap in safety management research regarding the order of the implementation of prospective and retrospective methods, and contributes to literature on incident reporting.
The pre-implementation period consisted of the 12 months before implementation of prospective bleeding risk stratification at each site.
Furthermore, we strongly recommend the implementation of prospective trials to assess properly the quality of life of elderly patients undergoing chemotherapy.
Design Prospective cohort study comparing the use of bleeding avoidance strategies and bleeding rates before and after implementation of prospective risk stratification for peri-procedural bleeding.
Our study provides evidence to justify the implementation of prospective studies to examine the possible impact of impaired markers of cardiovascular disease on lung function decline.
The results indicated that the majority of respondents perceived the impact of the Directive to be negative (75%), although a minority reported that it had made no difference or had a positive effect on the implementation of prospective clinical trials.
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In particular, I consider normative lessons for design and implementation, analysis of prospective and adopted systems, and identification of new applications.
Rigorous implementation of the prospective inception cohort study is challenging, and application to neonates renders it even more difficult.
We present the implementation of a prospective platform for evaluation and development of lung radiotherapy (proPED-LUNG) as an instrument enabling multidimensional predictive modelling.
The implementation of a prospective study examining primary and acquired drug resistance patterns is also necessary.
This paper describes the rationale for, and implementation of, this prospective cohort study.
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