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Rapid emergence of drug resistance is crucial in management of HIV infection limiting implementation of efficacious drugs in the ART regimen.
For example, the transactional model of stress and coping suggests that positive self-esteem can buffer stress by mitigating the perceived threat and by enhancing the selection and implementation of efficacious coping strategies, which in turn modulate physiological responses to stressors contributing to illness and physical health14.
Understanding microbicide pharmacokinetics is essential to development, characterization and implementation of efficacious microbicide drug delivery formulations.
This review demonstrated that implementation of efficacious ARV regimens for PMTCT is possible in PHCs in resource-constrained settings.
Implementation of efficacious but resource-intensive, research-based lifestyle interventions into real-world settings remains a challenge.
The review revealed that implementation of efficacious ARV regimes for PMTCT is possible in PHC in resource-constrained settings.
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ZPCT's technical support consisted of training on the implementation of the efficacious PMTCT regimen and continuous mentoring of healthcare providers.
The key to improving implementation of more efficacious ARV regimens for PMTCT in PHCs lies in building the capacity to determine CD4 cell count.
The objective of this review is to determine the uptake of and factors associated with implementation of more efficacious ARV regimens (beyond sdNVP) for prevention of mother-to-child transmission of HIV (PMTCT) among HIV-positive pregnant women in PHCs.
Factors associated with implementation of more efficacious ARV regimens included timing of blood-draw for CD4 count and capacity to initiate cART onsite where PMTCT services were being offered.
The technical and financial capacity necessary to close these gaps exists at the global level, but implementation of known, efficacious approaches in low-resource settings has been slow [ 2, 3].
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