Sentence examples for implementation of dose from inspiring English sources
Aristophanous and colleagues have recently investigated the implementation of dose painting in lung cancer radiotherapy planning using motion-managed PET, which introduces several challenges to prescribing dose to moving tumors, and in some cases, independently moving biological target subvolumes[82].
These studies could help in elucidating the details regarding the template for implementation of dose tracking in clinical settings locally and at higher levels.
For the studied drugs, implementation of dose banding should be considered as it entails no significant increase in interindividual plasma exposure.
The lower doses and corresponding risk estimates in the current work reflect the use of contemporary state-of-the-art low dose CT equipment and the successful implementation of dose reduction strategies for paediatric CT imaging by the participating radiology departments (as illustrated in Table 4).
Prescriptions for gentamicin initial dose and vancomycin initiation regimen (loading dose and first maintenance dose) written during the 8-month period (1 January 2011 31 August 2011) before implementation of the dose calculators were retrospectively assessed for appropriateness.
Questions covered the number of patients and treatments during 2015, involvement of medical specialties and medical physicists, implementation of absorbed dose planning, post-therapy imaging and dosimetry, and the basis of therapy prescription.
No patients treated after the amendment had treatment-related severe fatigue but such clinically important side effect was observed in four out of 13 cases treated before the implementation of the dose reduction policy (Fisher's test; P=0.04).
One confirmed partial response was reported among the cases treated before the protocol amendment and two confirmed partial responses were noted in the cohort included after the implementation of this dose adjustment policy.
In 1988, Canal et al. 88 suggested implementation of adaptive dose adjustment, based on PK and PK-PD models, to allow revision of the dosage after measurement of drug concentration and comparison of exposure metrics based on known PK-PD relationships.
Collectively, these data highlight the importance of (1) the use of quantitative tumour pharmacodynamic measurements to identify the level of target inhibition required for an optimal response, and (2) the implementation of various dosing schedules during early-phase clinical trials to find the proper dose that can achieve the desired level of target inhibition.
