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The quality of results and the generality of the approach indicate that there is a strong potential for extending the method to even larger historical datasets and to different operations, thus making it an advanced PAT tool that can assist the implementation of continual improvement paradigms within a quality-by-design framework.
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[1998 Practical implementation of a modified continual reassessment method for dose-finding trials. Cancer Chemother. Pharmacol. 41, 429 436] and Whitehead and Williamson [1998.
Coupled with its newfound success at adapting to changing market environments, and continual implementation of its international growth strategies, McDonald's could continue to provide excellent returns to shareholders for quite some time.
Our systematic approach to the design, development, implementation and continual improvement of online formative assessments is likely to have played a role in students' perceptions of the assessments, as well as their positive effect on student learning.
The Joint Commission in the US has established the expectation of continual readiness with the implementation of the unannounced survey in 2009.
It's a matter of continual debate.
This mood of continual slippage is not just temporal.
He had lived through two decades of continual fighting.
Its owners complain of continual hiccups, particularly in certain cities.
He registered the heat, the sound of continual rain.
They expect rehearsals to be a time of continual discovery.
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