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For example, they are the implementation of cells and cellular behaviors, such as division, adhesion, simulated physics; all kinds of non-signaling cellular interactions in general.
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Contradictory results in clinical trials are preventing the advancement and implementation of cell-based therapy.
However, the numerical implementation of cell-based models remains challenging, and little work has been done to understand to what extent implementation choices may influence model predictions.
The implementation of cell therapies and grafts in the clinic requires the recognition and resolution of several difficult issues.
Paralleling these technical achievements in cell manufacturing is the development of broadly applied regulatory standards that define the requirements for the clinical implementation of cell products with ever-increasing complexity.
The implementation of cell-based strategies is mainly limited by regulatory burdens and by the necessity to expand cells prior to transplantation resulting in high treatment costs.
First among these is the ScEM implementation of cell division.
However, a significant barrier to the effective implementation of cell therapy is the inability to deliver sufficient number of cells to the tissue of interest.
Here, we highlight the status of the most advanced and widely explored implementations of cell encapsulation with an eye toward translating the potential of this technological approach to medical reality.
In order to unveil some of the crucial stem cell-niche interactions and expedite the implementation of stem cells in clinical and pharmaceutical applications, in vitro methodologies are being developed to reconstruct key features of stem cell niches.
Such study allows inferring the requirements and constraints for the implementation of fuel cells in commercial AUVs.
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