The main goal of this paper is to design an individual-based stochastic dynamic framework to model the pertussis transmission in the population in order to predict the epidemiologic and economic consequences of the implementation of universal booster vaccination programs.
The aim of this study is to design an individual-based stochastic dynamic framework to model pertussis transmission in the population in order to predict the epidemiologic and economic consequences of the implementation of universal booster vaccination programs.
The output of the dynamic model, in terms of annual primary, recidive and asymptomatic infections, was used to estimate the economic consequences of the implementation of the adolescent booster vaccination program.
Before the implementation of the acellular booster vaccination at the age of 4 years, the efficacy of the whole cell pertussis vaccine used in the Netherlands was estimated at 89% [2], [22] [25].
Algorithm 1: The pseudocode implementation of the LDA-based booster.
The implementation of an adolescent pertussis booster vaccination program (technically, at t = 10) reduces the absolute incidence of all infection types (I1, I1 and I3) in the total population as shown in Figure 3.
However, to make a through-out decision about the implementation of such a pertussis booster vaccination strategy, one should first compare the cost-effectiveness of the adolescent vaccination with that of other vaccination strategies (e.g. adult vaccination or cocooning).
Objective To estimate the prevalence and clinical severity of whooping cough (pertussis) in school age children presenting with persistent cough in primary care since the introduction and implementation of the preschool pertussis booster vaccination.
16 This study aims to inform these discussions by estimating the prevalence and clinical severity of pertussis in UK school age children who present in primary care with persistent cough following the introduction and implementation of the preschool pertussis booster vaccination.
20 37 Our findings show that a significant burden of illness associated with pertussis remains among school age children who present in UK primary care with persistent cough, even after implementation of the preschool pertussis booster vaccination and despite high levels of vaccination coverage.
