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LD was new to the field of patient involvement in research and sought to maintain an open-minded approach in exploring its implementation in trials.
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The model may be used effectively to explain the implementation process in trials of complex interventions.
Given the growing importance of HRQL in HIV-infected patients while remaining cognizant of the burden associated with administering PRO instruments in clinical trials, it is important to carefully evaluate and select the most sensitive and appropriate HRQL measures for implementation in clinical trials.
Therefore, patient selection based on CTP images is not ready for implementation in clinical trials or clinical practice.
Growing interest in PRO measures and their implementation in clinical trials has resulted in more formal guidance on the design and properties of these instruments.
Our results indicate that case-based CTRSS can be suitable for practical implementation in clinical trials.
For example, the LLC model was a successful preclinical model for Navelbine evaluation in vivo, prior to its implementation in clinical trials [ 73, 74].
Ideally, for implementation in clinical trials, the findings should be confirmed in other large datasets in which similar instructions have been given to participants, with records of SABA use kept in a comparable way throughout the study.
In conclusion, the establishment of this collection holds great promise not only to further develop personalized approaches for the treatment of NSCLC patients but also for wide implementation in clinical trials of these xenograft models located at a distance from the collecting area.
The primary analysis was repeated with a random effects model, and the overall estimate was slightly larger; thus, heterogeneity is partially explained by small studies reporting larger effects (0.71, 0.61 to 0.84), which could be related to bias or to clinical differences (such as better implementation in small trials).
Even in that short time the emphasis on PPI has grown and our findings may not reflect the planning and implementation of PPI in trials funded more recently.
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