In some centres, BPR has been implemented for several years, whereas in others implementation is in the initial phase.
A second questionnaire was designed after the implementation of initiatives proposed in the initial audit and a 58% response rate was achieved.
After implementation of the initial guidelines in 1996, a decreasing GBS incidence has been observed over time (1.7 per 1000 live births in 1993 compared to 0.34 0.37 per 1000 in recent years) [ 12- 14].
The implementation evaluation allowed us to discover problems in the initial implementation and correct them with a change in evaluation design and eventually in personnel.
ROK was involved in securing funding for the study, had a role in the design of the study, had a major role in planning and managing the trial's implementation in its initial stages, recruited and supervised the study staff, established and maintained organisational support in the Southern Area, and had a role in the writing of the manuscript.
As makers, it's so easy to jump straight into design and implementation, but a mistake in the initial definition can haunt you and be very hard to fix later (much more than in software).
The brute-force implementation of ICE described in the initial study (Bae, 2008) had two steps: the creation of all the possible sequences given the allowable substitutions, and the average LSE calculation for the generated sequences.
In our proposed implementation, the initial guess of myocardial kinematic function and residual innovation of all the state variables are first computed using a Kalman filter via state space equations only driven by the Gaussian white noise, and then the residual innovation is fed into a least-squares filter to estimate the total external loads of the myocardium.
If e r r k >1, the step is rejected and redone with τ = τ 2. In a practical implementation, the initial step tests over q=1,…, k m a x, where k m a x is usually set as eight, in order to establish the k necessary to achieve the required accuracy and ensure the stepsize is reasonable; subsequent steps then test for convergence only in columns k−1, k and k+1 [ 28].
The penetrance estimates used in the current implementation of BRCAPRO were the latest for non-Ashkenazi carriers, which are lower than the Breast Cancer Linkage Consortium estimates used in the initial implementation [ 2, 3] and are closer to the estimates used in BOADICEA, although they are not cohort specific.
