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Even without implementation in additional applications, many cases of network transmissions could already be covered by enhancing the built-in services like web-browsing engine and download manager, for example.
Globally, with widespread recommendation for obstetric and neonatal simulation-based training, the feasibility of adapting PRONTO for implementation in additional low- and high resource settings should be assessed.
The main output of the ISOpure implementation in Additional File 1 are the tumor purity estimates α n and the cancer profiles c n.
It may also be advisable to provide training to potential resource persons (e.g., from local NGOs) who could later be used as resource persons in providing technical support in the FES implementation in additional aimags to be included later.
For calculations, we used the freely available R package phom [ 40] and their maximum weighted bipartite graph matching [ 41] as a measure of difference (see R script implementation in Additional file 5).
To estimate our parameters in Step 1 (and Step 2), we run 35 iterations of an optimization procedure that maximizes the complete likelihood function via block coordinate descent from a randomized starting point (see the ISOpure implementation in Additional File 1).
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Details about its implementation are in Additional file 8: Supplementary Methods.
The Pipeline Pilot implementation is shown in Additional file 1: Figure S2 and the workflow is available in Additional file 2. Data curation includes the removal of duplicates, inorganic molecules, mixtures, and salts, the standardization of chemical structures, the determination of protonation states at physiological pH (7.4) and the selection of the tautomeric state.
This implementation is available in additional file 1.
Additional information on the method's implementation is provided in Additional file 12.
Other characteristics of professionals that influence implementation are listed in Additional file 1 (column 3).
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