Further discussion on implementation is required; for example, it should be explored whether the reanalysis of study data with the aim of generating information on the approved patient population could already be routinely provided by the regulatory process (for example, in European public assessment reports).
While no additional implementation was required for the association rule mining, data preparation and harmonization as well as calculating the P-values using a hypergeometric distribution were implemented using Groovy, version 2.0.4 (http://groovy.codehaus.org/Download), and the Apache Commons Math library, version 3.3.2 (http://commons.apache.org/proper/commons-math/).
Furthermore assertive implementation strategies are required for overcoming resistance to change.
However, to achieve faster query performance and maintenance of the integrated databases, further implementation effort are required, for example, integrated query support, query optimization and user-friendly database management interfaces.
Since only standard optimization algorithms are required for implementation, these strategies are easily applicable to a variety of complex engineering problems.
It is possible to conclude from the above that the species-specific MA-rFTIR maps allow visualization of the distribution of these highly similar pigments in a straightforward and reliable manner, even though in its current implementation, very long acquisition times are required for this.
These data structure implementations have particular properties which are required for compatibility with the autograder.
