Whether it be WHO or ICH or FDA GMP standards, their implementation and enforcement is not a low cost exercise, as pharmaceutical companies and governments must develop capacity to implement and enforce the regulation.
This paper describes the design and implementation of a system for creating and enforcing licences containing location constraints that can be used to restrict access to sensitive documents to a defined area.
Integrating logic for checking and enforcing these invariants into the application's implementation is generally done by adding appropriate code to the functional application code.
Moreover, Monaco uses a state-of-the-art component approach with interfaces and polymorphic implementations, and enforces strict hierarchical component architectures that support hierarchical abstraction of control functionality.
Ministers with a short lifespan want to show they make a difference, so they reorganise and enforce local implementation (the last thing they want is annoying council leaders pointing out that their one size fits all policy won't work).
A Condom Use Working Group, consisting of police, local authorities, and health staff is set up to monitor, register and refer FSWs to assigned STI clinics and enforce programme implementation [ 8].
In order to maintain ecological security of western China, the following safeguarding principles need to be set up and enforced during the implementation of the GWDS.
That does not mean that we do not want to see the Working Time Directive for drivers enforced, and I would indeed call on the Commission to monitor implementation of the Working Time Directive and ensure that all countries monitor and enforce it in a uniform manner, so that there is no distortion of competition in this area, either.
Recently, it has been shown that human fibroblasts with a disabled p53 pathway and enforced p33ING1b expression failed to trigger efficiently cellular senescence [ 16], suggesting that the implementation of cellular senescence by p33ING1 requires an intact p53 pathway.
Many, though, are poorly designed and enforced.
