We addressed these questions by fitting our mathematical models of B cell population kinetics in the BM and in the spleen [25] [27], implementing this new hypothesis of T3 behavior, to the BrdU labeling data of Allman et al [28].
The multiplied term between IP3 and [m−m0]+ is to implement the hypothesis that the CS-US coupling may increase the efficacy of the slow component calcium kinetics (see below) with the baseline efficacy factor b and the coupling-induced contribution coefficient c of 1×10−3 and 0.1, respectively.
In this study we implement these hypotheses in the ecosys model to simulate water table dynamics along a boreal transition zone (ecotone) in central Saskatchewan, Canada, extending from upland black spruce forest down to a poor forested fen.
How to implement this strategy?
This argument is not restricted to humans and indeed the Gompertz law also applies to many animals (Vaupel et al. 1998), with different time scales for the slope b and the characteristic age X. Penna implemented this mutation accumulation hypothesis by dividing life into 32 time intervals and by representing the genome (DNA) through a string of 32 bits, each of which can be zero or one.
This section describes a neural architecture implementing the hypothesis described in Sect. 2, and a system-level model to study the interactions between multiple instances of such architecture.
Eq. (57) implements the hypothesis that the IDCN may have activity similar to that of the DCN, thus giving negative feedback of the output of the cerebellum to the IO system.
The implemented model supported this hypothesis.
Further biochemical and phenotypic investigations on these candidate genes should be implemented to validate this hypothesis.
Future studies should be implemented to explore this hypothesis; perhaps by investigating the effect of cistern use on diarrhoea while additionally collecting faecal samples to determine the agent responsible.
