Given how little research has been devoted to pediatric TTM and its treatment, this study represents an essential step in identifying and implementing efficacious treatments for youth with TTM.
The cornerstone in implementing efficacious ARV regimens is identification of HIV-positive pregnant women in need of cART for their own health.
Implementing efficacious health service intervention in a real-world resource-constrained setting is challenging and may not prove effective in improving patient outcomes.
However, it also highlighted three key bottlenecks in implementing efficacious ARV regimens: (1) capacity to assess CD4 count, (2) availability of CD4 count results at clinics, and (3) capacity to initiate cART.
21 This science-driven misapplication of the Public Health Model ignores the importance of engaging practitioners, policy makers and the community in the process of designing, researching and implementing effective interventions, falsely assuming that efficacious interventions can be automatically adopted and effectively implemented at a population level.
Beyond single-dose nevirapine regimens, rural primary health facilities likely face other difficulties as well, such as the capacity to determine the CD4 cell count required to implement more efficacious antiretroviral regimens [ 43].
One concern with regards to implementing partially efficacious vaccines is the issue of behavioral disinhibition, which occurs when vaccinated individuals believe they are protected from HIV infection and therefore increase the behaviors that put them at greater risk of exposure to HIV [6].
Implementing an efficacious health service intervention in a real-world resource-constrained setting is challenging and may not prove effective in improving patient outcomes.
As health-related expenditures continue to rise and access to care decreases, there is an increasing need to develop, implement, and promote efficacious and cost effective arthritis self-management interventions (AF et al 1999).
Practitioners are encouraged to use these standards to design and implement a consistent and efficacious brachytherapy program.
