Exact(1)
First, in order to implement a molecular clock, we selected only full-length sequences with reported isolation dates.
Similar(59)
Significant progress was made toward creating such a system by implementing a molecular dynamics and local minimization (MD-LM) strategy to simulate a system in which a protein (bovine pancreatic trypsin inhibitor; BPTI) encounters a materials surface (MgO) in water.
The extensions are: 1) the ability to simulate non-isothermal flows; 2) the ability to simulate low-speed flows by implementing a molecular description of the gas provided by the low-variance deviational simulation Monte Carlo (LVDSMC) method; and 3) the application to three-dimensional geometries.
Early suggestions for implementing a molecular computer with nucleic acids followed the encoding principle of genetic information [1].
The process of implementing a molecular genetic test for diagnostic use is complex and involves many levels of assessment and validation.
Using the program BEAST and implementing a molecular clock of 2% per million years [ 67- 69] we estimated a coalescence time of approximately 930,000 years with bounds of the 95% highest posterior density intervals (HPD) of 0.5 and 1.5 million yrs, dates that correspond to the middle of the Pleistocene.
We develop, validate and implement a range of molecular diagnostic technologies for improved and comprehensive testing that include Sanger sequencing, MLPA, array-CGH and next generation sequencing techniques including exome sequencing.
Our system implements a versatile molecular engine, including inter-molecule interactions and orientational variables for performing the Metropolis Monte Carlo (MMC) algorithm, which is one type of Markov chain Monte Carlo.
Implementing a stochastic molecular software showed the all-atom 2′-C-methylated analogue reaction within the active sites of wild type and serine-threonine mutant polymerases from Hepacivirus and Flavivirus.
We implemented a relaxed molecular clock, with an uncorrelated lognormal distribution for the substitution rate variation, and a coalescent model with constant size was assumed as tree prior.
The demographic history was analyzed on the third dataset on an individual basis by comparing the four coalescent models (constant, exponential, expansional, and BSP) and implementing a relaxed molecular clock model under the conditions described above.
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