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Heavy ion implantation of samples with fluences of 1012, 1013, 5 × 1013 and 1014 was performed at IC-100 cyclotron at Flerov Laboratory of Nuclear Reactions at Joint Institute for Nuclear Research JINRR) in Dubna, Russia.
The head of tibia/femur of the animals were used for the implantation of samples.
The head of the tibia/femur of the animals were chosen for the implantation of samples because they have been widely used as an animal model, and so, our results could be promptly compared [39 46].
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'Hot implantation' of the samples was performed at normal incidence at 400°C with Al+ ions using multiple-beam energies (30 to 80 keV) at a dose of 1.3 × 1015 cm-2 to form an almost uniform dopant profile (with an Al concentration of 1 × 1020 cm-3).
The rats that received the implantation of both samples were healthy throughout the implantation period.
The rats which received the implantation of all samples were healthy throughout the implantation period and no signs of inflammation (i.e., redness, swelling, pain, and heat) were observed.
After implantation a part of samples was annealed at 1000 °C for 3 min using rapid thermal annealing.
Development of "Mouse Avatars" entails implantation of patient tumor samples in mice for subsequent use in drug efficacy studies.
Implantation of Si fabric samples beneath the conjunctiva of rat eyes for 8 weeks demonstrated that the composite materials did not cause visible infection or inflammation, and did not erode the ocular surface.
In this set of experiments, tissue infiltration by activated neutrophils represented a nonspecific inflammatory response to dermal incision and subcutaneous implantation of cAAPEG hydrogel samples.
To contribute to the standardisation of testing new and biodegradable materials for use in orthopaedics, maxillofacial and dental surgery our research group has developed an animal model with sheep that allows the intraosseous implantation of 8 different samples per sheep in long bones [ 41, 42].
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