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Perhaps better techniques of RV protection during LVAD implantation need to be further explored as well.
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Optimization of the ion implantation needs further study.
Although the number of the reported cases is increasing, the decision for implantation needs thorough investigation.
In case of failed attempt in SU1, VAD implantation needs meticulous revaluation in particular of BiVAD because of high mortality.
Regarding to pregnancy rate and potentially adverse effects of drugs on endometrium or implantation needed more data.
With reference to our and other studies [ 10, 12, 17, 22], the effect of hormonal stimulation, including the estradiol levels at the time of implantation, needs to be investigated further.
The design of customized biomedical devices is certainly relevant nowadays, and to achieve higher implantation accuracy, custom-made implants need to be developed.
However, due to a shift to earlier (and bilateral) auditory implantation, the need to study children during general anesthesia appeared, since they are not able to cooperate during scanning.
Further, hydrogels for implantation also need to meet appropriate regulatory body (i.e., FDA, EPA) guidelines.
In summary, local sensory impairment seems to be a mild complication compared to the severe cluster attacks but the implantation procedure needs further attention.
Further exploration into etiology of delayed-onset hearing loss post implantation is needed, with particular interest in mechanisms associated with changes in the intracochlear environment.
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