Several challenges confound this goal, including imperfect empirical rules and parameters underlying predictions and the fact that folding algorithms scale poorly with respect to sequence length.
Cognitive error may also arise through biases that have become established through inferior strategies or imperfect decision rules.
Determining the sequence of nucleotides that would fold into a given structure is not a trivial problem, due to imperfect thermodynamic rules and additional constraints related to sequence synthesis or three-dimensional folding requirements.
In an election rife with false equivalences, it is useful to remember that heedlessly comparing unwrinkled authoritarianism to imperfect representative rule is a perversion akin to Trump's own manipulation of facts and exploitation of fear.
And it is just the marvelous logic of natural selection that makes it a bricoleur, arranging the better solution possible with "available stuff," a process by which we are not allowed to expect perfection, optimality, or cruel elimination of whatever is imperfect: The rule is that, whatever works, works.
It has survived centuries of conquest, decades of imperfect self-rule, and still continues to thrive, only because it is more democratic, egalitarian, and non-violent than critics or even supporters have ever recognized.
Although imperfect, those proposed rules marked an important step forward toward reining in the amount of secret money that infects our politics.
Several studies indicate that piRNAs in Drosophila have the capacity to downregulate the expression of certain mRNA targets via a miRNA-like mechanism that operates by imperfect base-pairing rules.
Small countries thrive in an open system of rules, albeit imperfect ones.
He is an Oscar-winning screenwriter for Gosford Park, a bestselling author with his novels Snobs and Past Imperfect, and now Julian Fellowes rules the small screen unchallenged thanks to his barnstormingly successful period costume drama Downton Abbey.
