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First, the effect of low MAF on accuracy and heritability may be somewhat exaggerated by the imperfect imputation of causal variants.
This may be due to imperfect imputation of sequence data due to the small reference size or may reflect that the density of the HD data was sufficient for QTL detection and further density increases only give small improvements.
This information can then be used in the analysis either as discrete genotypes in the case of perfect imputation or as genotype probabilities in the case of imperfect imputation.
Given the current state of available software, JAV is the best of a set of imperfect imputation methods for linear regression with a quadratic or interaction effect, but should not be used for logistic regression.
In view of this, we recommend that, given the current state of available software, JAV is the best of a set of imperfect imputation methods for linear regression with a quadratic or interaction effect, but should not be used for logistic regression.
Similar(54)
Therefore we can hypothesize that these SNP differences may arise from imperfect phasing and imputation for these SNPs with low LD.
Use of surrogates as imperfect measures of environmental exposures or imputation strategies to circumvent incomplete data issues is not studied in this paper.
This implied the imperfect efficiency and eurytopicity of SBSS, even with population-scale sequencing for imputation.
Imperfect finish.
Pitch imperfect.
The law is imperfect.
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