My imperfect but functional solution: take a picture and type it, complete with å's and ø's, into Google Translate when I got home.
This means that imperfect but functional novelties can provide important selective advantages before micro-evolutionary processes have had an opportunity to fine-tune them.
At least the sequence box TGACC is present in the CrAT L-carnitine binding site, therefore we propose in analogy to the CPT2 gene this sequence element being a further imperfect but functional PPRE site.
Although it has long been recognized that sequence similarity is an imperfect proxy for functional similarity, a fundamental dogma of structural biology that sequence conservation infers structural conservation, which in turn implies functional conservation has been extensively and effectively applied to infer functional properties on every scale.
However, the periodic insertion and fixation of ten NANOG pseudogenes with a complete or partial reading frame should have left a record, albeit an imperfect one, of the functional NANOG gene-sequence evolution.
We agree with the reviewers that LTNPs represent an imperfect surrogate group for functional cure, however, we believe that they represent some of the presently best available examples of viremia control with limited immune suppression over the long-term and this in the absence of a better comparator group of patients.
However, in our experience, imperfect alignment between fieldmaps and functional data, and the difficulty of accurately interpolating fieldmap data when distortion is severe, limit the utility of distortion compensation techniques for severe artifacts on the edge of the brain.
Although clinicians are able to recognise severe geriatric impairments, their sensitivity to detect moderate impairments or change in functional impairment is imperfect.
This may also reflect an imperfect segregation apparent in the functional characteristics of the cardiac vagal ganglia in individual rats where selective electrical stimulation of the ganglia was attempted (Sampaio et al., 2003).
Reciprocal attenuation of the effects for these two signals when allele dosage for an opposite variant is included into a model raises the possibility of an underlying haplotypic effect (r = 0.17, D′ = 1.0 between these two SNPs) or an imperfect correlation with an unknown functional variant.
