In fact, 1000 mg of cyclophosphamide as an imperative treatment can still be highly tolerated by patients with immune diseases, including lupus nephritis and chronic kidney disease [ 16].
It was also stated essential to, nationally and internationally, significantly enhance the surveillance of AMR (maintaining culture is imperative), treatment failures and antimicrobial use/misuse locally (strong antimicrobial stewardship crucial).
However, it is imperative that treatment guidelines and the decision processes for determining access to treatments be tied to a solid evidence base with rigorous standards for robust and consistent data collection.
Not only is this imperative for treatment purposes, but it is also important for systematically evaluating the disease process.
The high incidence of thrombotic disease despite prophylaxis makes early detection imperative, as treatment with anticoagulation is highly effective [ 4, 5].
In some cases, attempts were made to encourage the patient to see the medical imperative for treatment They don't want to take any tablets; you say 'well you probably will die in 5 years time at the most without these things.
Due to the relatively high rate of infection by Candida species [ 9], the associated mortality [ 10], the high costs of hospitalisation [ 11], and the increasing prevalence of non- albicans Candida species [ 1], it is imperative that treatments that are both clinically and cost-effective are identified.
Because different patients have distinct risk factors associated with their CLL, it is imperative to tailor treatment strategy to the individual patients' disease.
Thus, it is imperative to initiate treatment in the most expeditious manner possible to prevent the dysfunction, disability, morbidity, and mortality that all too often accompanies bipolar disorder, and often occurs as a function of the number of prior episodes (Kessing and Andersen, 2017; Post et al, 2012).
