Therefore, it is imperative to determine the surgical outcomes of major oncologic procedures.
It is therefore imperative to determine existence of non-identifiability and asses its impact on the results.
It is imperative to determine the main causes of LRP so as to capture the uncertainty range and define the best technique to evaluate the reservoir parameters.
In the broad landscape, it will be imperative to determine how the EndMT process is orchestrated, and what its context dependencies may be.
Therefore, it is imperative to determine the best system configuration in order to produce efficient and economically viable PEM fuel cell systems.
As a consequence the mass of at least one neutrino has to be different from zero and it becomes imperative to determine its absolute value.
Thus, it is imperative to determine the vulnerable regions in these landscapes to identify priority areas that may require immediate intervention.
For instance, given two sets A and B, set theory allows us to construct their Cartesian product A × B. It is also imperative to determine how given structures can be decomposed into more elementary substructures.
Second, and perhaps even more important, once a type of structure has been defined, it is imperative to determine how new structures can be constructed out of the given one.
Before targeting Nrf2 for PD therapy it is imperative to determine if HO-1 is neurotoxic or neuroprotective in the basal ganglia.
