According to the data in Figure 7, calpain II was instantaneously activated early and its inhibition strikingly reduced nucleosomal release with no influence on cellular viability, indicating that instant early calpain activation is not crucial for cell death but needed for the imperative process implicated in nucleosomal and DAMPs release, possibly by regulating Cl− channel activity.
Thus it is imperative to develop cost effective and scalable process for the production of vaccines so as to make them affordable for mass use.
"For a county with over 10 million residents … it is imperative that we have a fair and impartial process for drawing districting boundaries," Lara told his colleagues.
There is an urgent imperative to gain a better understanding of this process for two simple reasons.
Thus, it is imperative to develop a new method of accelerating the discovery and design process for novel materials.
The state process for determining healthcare benefits will be influenced by budgetary imperatives that emphasize maximal cost containment over maximal effectiveness in care.
The hypertrophic chondrocytes of the epiphyseal growth plate mineralize their surrounding ECM and facilitate the deposition of HA, a process imperative for longitudinal bone growth.
Particularly important and imperative for commercial processes is selectivity at acceptably high conversions.
Moreover, it is imperative to develop more efficient processes for sharing and extending best practices between the former NHS trusts, while recognising that there are constraints on the extent to which some best practice can be shared and scaled up.
For that reason, interactions such as President Hu's visit are imperative for the educational process, Mr. Levin said in an interview, even when they come with a great deal of political baggage.
Acute-phase activation of crucial immune processes is imperative for survival and initiation of wound healing, otherwise inflammation may become detrimental when caused by intercurrent infection or diseases such as sepsis or pancreatitis.
