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It is imperative, first of all, that responding to the hepatitis C epidemic is part of the public agenda, that both policymakers and communities are aware that the problem exists, and that they understand what can be done to prevent and treat it.
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But, it's an imperative first step.
Instances of direct influence include Kant's idea of the categorical imperative, the third formulation of which in the Groundwork of the Metaphysic of Morals (the so-called formula of the kingdom of ends) recalls Rousseau's discussion of the general will in The Social Contract.
Or, how could biological systems generate and maintain their internal order in the face of the imperative of the second law of thermodynamics that all natural systems proceed with increasing entropy?
Positional information determines cell differentiation, cellular compartmentalization and subsequent unit placode initiation, the first of which is imperative for iterative initiation of adjacent placodes via activator-inhibitor mechanisms [ 2].
Despite these benefits of GMOs, it is imperative to first understand the risks of producing GMOs before introducing them into the wild.
It was a response of R&D to Ian Read's first imperative of fixing the innovative core of the company.
To understand the biological consequences of clinically used mutagens, it is imperative to first characterize the spectrum of mutagenic changes caused by these agents in a biological context.
Ms. Hutchinson, who has a sharp ear for dialogue (most of her best lines can't be printed here), gets many things right: a health teacher's lecture involving a banana and a condom; the casually cruel banter of high school students (Lavita Shaurice shines as a tart-tongued locker room tyrant); the hesitations and imperatives of first love.
This is a hard challenge but a moral imperative of the first order, as the Prime Minister of the United Kingdom stated in the DFID White Paper on Making Globalisation Work to Eliminate World Poverty [ 13].
In seeking to dismantle racism, it is imperative to first acknowledge that these manifestations of racism don't happen just because of a few social miscreants.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com