The present modeling studies confirm the critical contribution of the R325 residue to PIP2 binding in the proximal C-terminal pocket in Kv7.2 subunits; substitution of the positively-charged arginine with a smaller, non-polar glycine may significantly weaken such structural stabilization, impeding the translation of the electromechanical forces triggered by VSD displacement into pore opening.
Researchers consider that several factors are impeding the translation of biomarkers into the clinic.
This review highlights novel findings from a DMD mouse model utilizing systemic multiexon skipping targeting exons 45 55, discusses the major hurdles and limitations impeding the translation of this approach into clinical therapies along with the potential solutions, and provides a perspective on the future of clinical exon 45 55 skipping in DMD patients.
Over the past decade, the National Institutes of Health (NIH) roadmap has sought to bridge the gaps among our research silos, which have impeded the translation of evidence from bench to bedside, from bedside to community, and from community to populations (Zerhouni 2003).
Or you may seriously impede the translation of your project into other projects--stage plays, radio broadcasts, etcetera.
It has now been shown that Hfq impedes the translation of the major stress sigma factor, σS (RpoS) in the enteric bacteria viz E.coli and Salmonella [25], [26].
Applying this model, called the top-down approach, impedes the translation of research into practice in the public health field.
DFs bridge the gaps between research and practice, filling the 'structural holes' 13 between the two communities that impede the translation and implementation of evidence.
However, the precise mechanism involved in ER stress-induced cardiovascular diseases has not been well identified, which impedes the translation of our understanding of ER stress-induced cardiovascular anomalies into effective therapeutic strategies.
Finally, it is important to acknowledge that actual translation is much more complicated as different forces such as private investments in research and development, policy and legal frameworks, oversight and regulation, product marketing, coverage and reimbursements, consumer advocacy, provider awareness, and consumer access can accelerate or impede the translation process.
Different forces can accelerate or impede the translation process, such as private investments in research and development, policy and legal frameworks, oversight and regulation, product marketing, coverage and reimbursements, consumer advocacy, provider awareness, access, and health services development and implementation [ 17, 18].
