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The target engagement of HDAC subtypes 1, 2, 3, and 6 in living rodent brain has not yet been evaluated, impeding the interpretation of treatment effect relationships for myriad HDAC inhibitors in preclinical research.
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Important fundamental issues are highlighted that remain to be elucidated, and that could impede the interpretation of a number of macroscopic observations.
In any case the large confidence intervals impeded the interpretation.
However, the surveillance commonly applied is hampered by methodological pitfalls that impede the interpretation of the surveillance findings [ 2].
However, the average length of the 37 LADs on chromosome 16 is 1.26 Mb, impeding the direct interpretation of the mechanistic significance.
Furthermore, some non-pathogenic Clavibacter strains showed fainter PCR amplicons on the gel impeding the correct interpretation of the results [ 4].
Third, the vast majority (over 90%) of associated variants have been found to localize outside of known protein-coding sequences, thus impeding the direct interpretation of their functional effects 11.
Since the choice of the threshold might not be optimized, the apparently poor performance of a tool is probably due to human errors rather than the algorithm itself, and this will lead to the incomparability of different tools, thus impeding the development of interpretation guidelines.
But incomplete access to those databases threatens to impede the clinical interpretation of genomic medicine.
Also, notice venous intravasation of the contrast medium (this can impede the image interpretation).
Speckle may impede the correct interpretation of structural features in OCT.
More suggestions(12)
impeding the translation
precluding the interpretation
jeopardizing the interpretation
impeding the view
hindering the interpretation
impeding the construction
undermine the interpretation
prevent the interpretation
obstruct the interpretation
hinder the interpretation
impeding the understanding
impeding their
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com