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We speculate that excess neuron numbers may be one possible cause of early brain overgrowth and produce defects in neural patterning and wiring, with exuberant local and short-distance cortical interactions impeding the function of large-scale, long-distance interactions between brain regions.
The semidominant alleles are thus a result of the mutant ChlI proteins, which do not have full ATPase activity, impeding the function of the wild-type ChlI subunits in the hexameric ring.
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They are undermining American leadership in Asia, impeding the functioning of the national security machinery, upsetting global markets and raising questions about the political dysfunction of a country that has long been the world's democratic standard-bearer.
This transit movement of quorum-sensing biomolecules inside or outside the bacterial cells may get interrupted by impeding the functioning of efflux pumps.
While it is recommended by several international instruments to grant migrants the right to change their employer, two out of the four analysed case countries do not fully comply with this recommendation.3However the cases of New Zealand and France demonstrate that a change of policy is possible and works for the benefit of the workers, without impeding the functioning of the whole scheme.
They can also impede the function of the the tiny airways deep in the lungs where incoming oxygen is delivered to the blood.
Indeed, I have been concerned for some time that clogged credit markets had impeded the function of the market, and that prices would therefore overshoot dangerously on the way down.But I seem to have been mistaken.
Small reductions in extracellular pH (on the order of 0.25) impede the function of the Cav1.4 presynaptic calcium channels [28], involved in synaptic transmission between photoreceptors and bipolar cells.
The latest hypothesis is that PFOS may impede the function of the endogenous pulmonary surfactant needed to inflate the lungs, he says.
They also support the feasibility of NRP2-based therapy for the treatment of TNBC that targets and impedes the function of TICs.
Abnormal tumour vessels can also impede the function of immune cells in tumours, as well as the transport and/ or distribution of chemotherapeutics and oxygen.
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