We hypothesized that association of Wnt with a lipid vesicle, either during autocrine/paracrine signaling or when packaged in a liposome, might impede the activity of the antagonists.
mTOR catalytic site inhibitors directly target the kinase domain of mTOR and therefore impede the activity of both m TORC1 and mTORC2 kinases.
A thorough understanding of the interactions of E6 with its numerous cellular protein partners, as well as the consequences of these interactions, allows for the possibility of developing therapeutic approaches to impede the activity of the oncoprotein.
Small changes in the free energy of ATP hydrolysis would impede the activity of key intracellular ATPases such as the sarco/endoplasmic reticulum Ca2+-ATPase, the myosin ATPase or the Na+-K+-ATPase.
Lignin is thought to impede the activity of CAZymes in part because of non-productive binding of enzymes to its surface and/or through steric hindrance due to the lignin-carbohydrate complexes that decrease cellulose accessibility [ 22, 24– 33].
YM (if multiple copies of M are present), IIIM, and VM show strong male-determining effects in the soma and impede the activity of Md-tra when introduced into the female germline by transplantation of progenitor germline cells (Schmidt et al. 1997b).
If we did not do so, the volume of traffic would begin to impede the activities of other areas of the university".
This latest tool could also be used in a wholly invasive way and could fly in the face of the role of the police to facilitate rather than impede the activities of democratic protesters".
The amendments, if adopted in two additional votes, would label as extremist those who "impede the activities of state bodies" or organize or take part in public disturbances, according to news reports.
Endocrine agents abrogate oestrogenic signalling through distinct and incompletely overlapping mechanisms, either impeding the transcriptional activity of ERα or diminishing E-synthesis.
