While amenable to biodegradation and, in fact, traditionally neutralized by aerobic microbiological processes, our current lack of understanding of the enzymatic degradation of Tph at the molecular level presents a major impediment in the development of robust bioremediation strategies.
A major impediment in the development of anti-cataract drugs is the lack of a specific animal model that mirrors the biochemical, physiological, and oxidative mechanisms observed in man.
However, administration of anti IL-7 to the KO animals severely reduced their CTL response (Figure 1F) further emphasizing that the absence of both IL-7 and IL-15 can cause a severe impediment in the development of antigen-specific CD8+ T cell immunity against Toxoplasma infection.
A major impediment in the development of novel vaccines has been the lack of safe yet effective vaccine adjuvants.
A major impediment in drug development against melanoma metastases is the lack of reliable animal models that can predict tumor response to therapy.
Despite progress in the treatment of several cancers over recent decades, the lack of clinically relevant tumour models for individual subtypes of human cancer has proven to be a major impediment in the development of effective anti-cancer therapies [ 1].
Then again, if grandiosity were an impediment to development in New York, there would be no Rockefeller Center, no Brooklyn Bridge, no Central Park, no subway system.
These two results are extremely positive for tidal stream developers in the region since it removes the burden of assessing cumulative impact from individual developers and suggests that impacts to sub-sea morphodynamics is insignificant and hence is unlikely to be an impediment to development in the Pentland Firth with the currently proposed levels of extraction.
Such a reality is a serious impediment to development in our countries; it represents a serious threat to social peace and is morally outrageous.
The secondary cell wall polymer lignin impedes the extraction of fermentable sugars from biomass, and has been one of the major impediments in the development of cost-effective biofuel technologies.
Open defecation is rife, and remains a major impediment in achieving millennium development goals which include reducing by half the proportion of people without access to basic sanitation by 2015.
