Conceptually, this finding represents a safety feature whereby any virus induced by the latency activator is also inactivated by the protease inhibitor, thereby impeding virus spread.
We also observed that expression of HLA-DM was sufficient to induce Gag retention and impede virus release from cells.
Nasal swab specimens were collected from experimental animals on 2, 4, 5, 6, 7, and 8 dpi to examine the ability of the vaccine to impede virus replication in the upper respiratory tract.
Therefore it is likely that CIITA is capable of increasing Gag-Pol levels to a point which can impede virus maturation, albeit not enough to reduce it to levels observed from vector-only expressing cells.
PIs inhibit HIV-1 and HIV-2 proteases (which are aspartate proteases), impeding virus replication and release of infecting viral particles from diseased cells.
Squash seeds called protease trypsin inhibitors that impede viruses and cancer causing compounds from becoming activated in the intestinal tract.
One limit on its complete success, besides immune attack, is that tumors often contain layers of normal tissue that impede the virus from gaining access to cancer cells.
So far, general evolutionary pressures shaping capsid design have remained elusive, even though an understanding of such properties may help in rationally impeding the virus life cycle and designing efficient nano-assemblies.
It would be interesting to explore whether deliberate induction of the imperfect centrosome orientation by taxol may strike the right balance, impeding the virus spread sufficiently for it to be cleared by the immune response, but not disrupting the immunological function of T cells to a dangerous extent.
As an example, a study with a poliovirus mutant which displays a -3-to 5-fold higher template-copying fidelity than the wild type documented that a narrow mutant spectrum impeded the virus to reach the brain of susceptible mice and produce neuropathology [ 6, 7].
