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To prevent glycerol efflux, Hog1 action impedes the function of the aquaglyceroporin Fps1, in part, by displacing channel co-activators (Rgc1/2).
They also support the feasibility of NRP2-based therapy for the treatment of TNBC that targets and impedes the function of TICs.
Binding of RK-33 to DDX3 impedes the function of DDX3, resulting in activation of cell death pathways, inhibition of the Wnt-signaling pathway, and abrogation of non-homologous end-joining (NHEJ) activity.
In some animals the mass occupies so large a volume of the mid-body region that it potentially impedes the function of the intestine, which could compromise the nutritional status of aging worms.
In human cells, even a marginal increase in histones H3 and H4 impedes the function of Asf1 and prevents chromatin disassembly, indicating that changes in the level of histones can directly influence the properties of proteins involved in their biogenesis [ 36, 55, 73].
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Perchlorate impedes the functioning of the thyroid gland, which produces hormones that foster mental and physical development and control metabolism.
This increase in fluid build up especially around the lungs impedes the functioning of the heart, causing an increase in blood pressure.
It was reasonably speculated that high glucose-induced ER stress on mesangial cells impedes the functions of cell migration and contraction, which influences the regulation of GFR.
They can also impede the function of the the tiny airways deep in the lungs where incoming oxygen is delivered to the blood.
Indeed, I have been concerned for some time that clogged credit markets had impeded the function of the market, and that prices would therefore overshoot dangerously on the way down.But I seem to have been mistaken.
We speculate that excess neuron numbers may be one possible cause of early brain overgrowth and produce defects in neural patterning and wiring, with exuberant local and short-distance cortical interactions impeding the function of large-scale, long-distance interactions between brain regions.
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