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To make the transition smoother we have changed the sentence as below: "During scanning, the GTP bound to eIF2 in the TC is hydrolyzed in the 43S PIC in a manner dependent on the GTPase activating protein eIF5, but Pi release is blocked by eIF1, which also impedes stable binding of Met-tRNAi in the P site".
The concentration of GelMA was chosen from a range which is above a lower critical concentration of hydrogel formation (4.5 wt %) and below a concentration that impedes stable droplet formation within microchannels due to its high viscosity (15 wt %; Figure S3 in Supporting Information).
During scanning, the GTP bound to eIF2 in the TC is hydrolyzed in the 43S PIC in a manner dependent on the GTPase activating protein eIF5, but Pi release is blocked by eIF1, which also impedes stable binding of Met-tRNAi in the P site.
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Additional blocks at the level of reverse transcription and integration may further impede stable transduction of naïve cells with non-viral sequences, accounting for a nearly eight orders of magnitude difference between the replication efficiencies of constructs with or without specific retroviral cis-elements[10].
Thus, DNA hypomethylation in Tert−/−S ESCs arose in response to critically short telomeres and impeded their stable differentiation.
In contrast, the agonist-bound conformation of the human corticotropin-releasing factor receptor is considerably less stable, impeding the formation of good quality crystals for structure determination.
Being undocumented has always been a precarious way to live, but the increased targeting of migrants under Trump has further impeded building a stable life.
Most proteins are only barely stable, which impedes research, complicates therapeutic applications, and makes proteins susceptible to pathologically destabilizing mutations.
Furthermore, proline substitution impeded the formation of stable amphipathic structures, rendering P LLKK 2P as one of the least active analogues.
As shown in Figure 2C, the cell growth was significantly impeded in the RND3 stable expression cell line (solid blue line) while the cell growth was facilitated in the RND3 knockdown cell line (solid red line).
Persistent denial of historical injustices not only impedes democratization but also hampers stable relations between different ethnic and religious groups.
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CEO of Professional Science Editing for Scientists @ prosciediting.com