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Second, an electrostatic repulsion between PH domains further impedes dimerization.
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Second, SARS-CoV PLP and PLP2 of HCoV-NL63 and PEDV also interact with and impede the dimerization of stimulator of IFN genes (STING, a.k.a, MITA/MPYS/ERIS) (Sun et al., 2012a).
It impedes STAT3 DNA binding activity, STAT3 dimerization and STAT3-dependent luciferase activity.
It impedes STAT-3 DNA binding activity, STAT-3 dimerization, and STAT-3 dependent luciferase activity.
We found that (1) SARS-CoV PLpro-TM inhibits the activation of transcription factor IRF3 and negatively modulates the IFNβ signaling pathways, which results from PLpro-TM impeding STING- and TBK1-activated phosphorylation and dimerization of IRF3.
The immobilization of DGCs for continuous c-di-GMP production is challenging because the dimerization and conformational changes accompanied with the chemical transformation could be impeded by the entrapment of the enzyme.
"Nothing here impedes that".
The choreography continually impedes, blocks, obstructs.
Time-out impedes democracy".
Instead of supporting, it impedes.
But that impedes deep understanding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com