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10.7554/eLife.01612.015 Figure 4. Loss of Fis1 or TBC1D15 impedes clearance of damaged mitochondria.
These results indicate that the Fis1-TBC1D15 pais is not essential for mitophagy but the deletion of either impedes clearance of damaged mitochondria, despite the greater magnitude of LC3 accumulation following Parkin translocation.
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Inflammatory changes of cervical epithelium, microabrasions of the epithelium and host immune response may facilitate (re) uptake of HPV and/or impede clearance [ 27, 30].
Alternatively, cerebral hypoperfusion and reduced vascular pulsation may impede clearance of Aβ as it is hypothesized that motive force of vessel pulsation is required for perivascular clearance of interstitial fluid containing Aβ [ 47].
A principal characteristic of high-aspect-ratio nanoparticles that is shared by pathogenic fibers, such as asbestos, is impeded clearance from the lungs after inhalation exposure, which may lead to the pathogenesis of diseases such as pulmonary fibrosis and mesothelioma (Bonner 2010).
Reduced activity of hepatic SR-B1 impedes HDL clearance and increases serum HDL levels [45], [46], [47].
In the lung, such abnormally thick mucus impedes mucociliary clearance and could secondarily damage the ciliated cells, which are unable to clear it (Houtmeyers et al., 1999; Voynow and Rubin, 2009).
On the other hand, IL-10 can impede parasite clearance by down-regulating the inflammatory response.
Bacterial capsular polysaccharides (CPS) have been extensively studied as virulence factors due to their ability to impede organism clearance by host antimicrobial systems, such as phagocytosis by professional phagocytes and complement mediated killing.
While the anti-inflammatory properties may induce immunoparalysis and impede bacterial clearance, the tissue protective effects might limit organ damage.
The impaired dendritic cell emigration from the skin parallels impeded migratory clearance of monocyte-derived dendritic cell-like cells from atherosclerotic plaques.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com