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RNA-seq suffers from an expression-dependent bias that impedes characterization of low-abundance transcripts.
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The complexity of the reactions impedes the characterization of UPPS inhibitors by traditional enzyme kinetics.
The genetic background in which a specific Dn gene is bred may also play a role in the successful establishment of a resistant phenotype, impeding their characterization (van der Westhuizen et al., 1998a; van der Westhuizen et al., 1998b).
Although similar levels of CD11c and MHCII expression by intestinal DCs and MΦs have impeded reliable characterization of DCs in the past, recent advances in phenotyping now allow these cells to be more precisely discriminated.
Electrochemical impedance spectroscopy characterization revealed that the MIC of Ni was impeded by over 40-fold when coated with graphene.
The low concentration of the hydroperoxy species (5) that accumulates during the second stage impedes more detailed characterization of its properties and its contribution to the conversion of NHA into nitric oxide and l-citrulline.
However, when inserted in the third intracellular loop (i3 loop), the soluble protein domain disrupts their coupling to G proteins and impedes the GPCRs functional characterization by standard G protein-based assays.
Mitochondrial protein (MP) dysfunction has been linked to neurodegenerative disorders (NDs); however, the discovery of the molecular mechanisms underlying NDs has been impeded by the limited characterization of interactions governing MP function.
In the present article we report the finding and characterization of impeded ductal morphogenesis in virgin SirT1ko/ko mice and lactation failure in SirT1ko/ko mothers.
Therefore, the conditions used to impede autoprocessing for structural characterization can reduce the population of the high-energy reactive states such that they are impossible to observe through X-ray crystallography, thereby explaining the overwhelming tendency of autoprocessing systems to crystallize in inactive forms.
However, the lack of specific cellular surface markers for these cells has impeded their isolation, making the characterization of this cellular subpopulation technically challenging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com