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Constitutive activation of NF-κB impedes activity of the tumor suppressor p53, a prominent hub in DNA-induced cellular stress networks and regulator of cellular senescence [ 67].
This implies that while topoIIα can function perfectly well without a C-terminal domain, the β-tail on the topoIIα enzyme impedes activity.
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Possible interactions with serum proteins may also impede activity, particularly when the peptides bind to abundant proteins in blood plasma such as human serum albumin (HSA).
Dizziness is known to impede activities of daily life [ 30] and to interfere with workplace activities [ 1].
Also in the direction of being disoriented, dementia diseases which impede activities of daily living…' (R2/29) '…and for most of the elderly the fear of intrusion of strangers, fear to be alone, fear of isolation…' (R9/163) Another identified problem is the thinning of the social environment because of deceased family members and friends.
Epigenetic modifications and disruption of Nuc-1, a nucleosome located immediately downstream of the transcriptional initiation site that directly impedes LTR activity, are a prerequisite to the activation of LTR-driven transcription and viral expression (Van Lint 2000; Van Lint et al. 1996; Verdin et al. 1993).
If the insertion of the tail per se impedes catalytic activity, then the topoIIβ (S165R)+α tail would be expected to have still lower decatenation activity than topoIIβ(S165R).
If lactate accumulates to high levels, it impedes cellular activity [[10]] and decreases the final 1,3-PD concentration by consuming NADH [[6]].
The local community considers the bridge inadequate, and feel it now impedes commercial activity.
Despite talk of a "dictator's dilemma", censorship technology is sophisticated enough to block politically sensitive material without impeding economic activity, as China's example shows.
Since then, encroaching coral reefs have impeded harbour activity, but redevelopment of Sawākin as the country's second port has continued.
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