Important fundamental issues are highlighted that remain to be elucidated, and that could impede the interpretation of a number of macroscopic observations.
However, the surveillance commonly applied is hampered by methodological pitfalls that impede the interpretation of the surveillance findings [ 2].
The target engagement of HDAC subtypes 1, 2, 3, and 6 in living rodent brain has not yet been evaluated, impeding the interpretation of treatment effect relationships for myriad HDAC inhibitors in preclinical research.
Also, notice venous intravasation of the contrast medium (this can impede the image interpretation).
Speckle may impede the correct interpretation of structural features in OCT.
But incomplete access to those databases threatens to impede the clinical interpretation of genomic medicine.
However, the average length of the 37 LADs on chromosome 16 is 1.26 Mb, impeding the direct interpretation of the mechanistic significance.
Furthermore, some non-pathogenic Clavibacter strains showed fainter PCR amplicons on the gel impeding the correct interpretation of the results [ 4].
Third, the vast majority (over 90%) of associated variants have been found to localize outside of known protein-coding sequences, thus impeding the direct interpretation of their functional effects 11.
This inherent complexity impedes the mechanistic interpretation of a chemical insult and may ultimately preclude what appear as more desirable in vitro methods from completely replacing whole-animal experiments in developmental toxicology.
