They can also impede the function of the the tiny airways deep in the lungs where incoming oxygen is delivered to the blood.
We speculate that excess neuron numbers may be one possible cause of early brain overgrowth and produce defects in neural patterning and wiring, with exuberant local and short-distance cortical interactions impeding the function of large-scale, long-distance interactions between brain regions.
Small reductions in extracellular pH (on the order of 0.25) impede the function of the Cav1.4 presynaptic calcium channels [28], involved in synaptic transmission between photoreceptors and bipolar cells.
The latest hypothesis is that PFOS may impede the function of the endogenous pulmonary surfactant needed to inflate the lungs, he says.
They also support the feasibility of NRP2-based therapy for the treatment of TNBC that targets and impedes the function of TICs.
Abnormal tumour vessels can also impede the function of immune cells in tumours, as well as the transport and/ or distribution of chemotherapeutics and oxygen.
To prevent glycerol efflux, Hog1 action impedes the function of the aquaglyceroporin Fps1, in part, by displacing channel co-activators (Rgc1/2).
Although wound closure is essential for maintaining tissue integrity, scars impair movement and can impede the function of some tissues and organs [ 30].
In some animals the mass occupies so large a volume of the mid-body region that it potentially impedes the function of the intestine, which could compromise the nutritional status of aging worms.
The semidominant alleles are thus a result of the mutant ChlI proteins, which do not have full ATPase activity, impeding the function of the wild-type ChlI subunits in the hexameric ring.
