Interviews were often undertaken in two sessions, when respondents indicated needs to meet other schedule demands or reported levels of fatigue that impeded responses.
Potential barriers that can impede response despite combination therapy are also discussed.
The variation in a population can therefore increase or impede response to selection, depending on whether or not it is correlated to the change under selection [1].
Variation within a population is a key feature in evolution, because it can increase or impede response to selection, depending on whether or not the intrapopulational variance is correlated to the change under selection.
Whether specific molecular abnormalities can facilitate or impede response to therapy is a crucial issue in oncology (Tanner et al, 2006).
Taken together, these results suggested that spatial heterogeneity at treatment baseline (assessed by ROS1 copy number between primary tumor and CTCs pretreatment) did not impede response, but subsequent temporal heterogeneity of ROS1 copy number (assessed in CTCs before and during treatment) emerged in parallel with tumor progression.
Chiefly, lead can damage and eventually kill neurons through its oxidative toxicity, whereby lead both induces oxidative stress (Acharya and Acharya 1997; Adonaylo and Oteiza 1999b) and impedes responses to oxidative stress (Adonaylo and Oteiza 1999a; Ercal et al. 1996) in the brain.
A number of the students identified that working alone was problematic and impeded their response.
Normally, bottlenecks are expected to reduce genetic variability and hence impede response to selection (e.g. [ 42, 43]).
Small, isolated populations are subject to genetic drift and inbreeding; these processes tend to cause decreased fitness, decreased tolerance to environmental stress, and impeded adaptive responses to changing environmental conditions (K. Bijlsma in Grant et al. 2010).
