Yet, studies using moral dilemmas suffer from two main shortcomings: they lack methodological homogeneity which impedes reliable comparisons of results across studies, thus making a metaanalysis manifestly impossible; and second, they overlook control of relevant design parameters.
Indels were not called because alternative splicing may impede reliable indel discovery.
Indels were not considered because alternative splicing impedes reliable indel discovery.
This simplifies image comparison and speeds up analysis dramatically but still produces expression profiles with gaps which significantly impede reliable gene expression analysis.
This low level of conservation in amino acid sequences impeded a reliable survey of the complete superfamily (Adams et al. 2000).
Moreover, PDMS-based microfluidic devices are known to absorb small hydrophilic molecules and so impede reliable drug transfer studies37,38,39.
Although these overlapping features have led to the development of pharmacological or surgical therapies effective in both diseases [ 9- 12], the similarities at the same time impede a reliable discrimination of the two arthritides.
However, methodological issues regarding the study design (i.e. set-up of monitoring devices, predefined measurement points during the perioperative course of cardiac surgery, measurements taken early after cardiopulmonary bypass) may impede a reliable trend analysis.
The branch leading to medaka also showed a d N/d S value similar to that of cichlids; however, individual values of d N and d S were extremely low (<10−4), impeding a reliable estimate of the ratio.
What is more, this thresholding approach has the severe drawback that the fraction of labeled cells is highly sensitive to the value of the threshold, which can usually not be determined exactly, impeding a reliable estimation of proliferation parameters.
