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Small glossy black soybean (Glycine max) lectin impeded proliferation of breast cancer MCF7 cells and hepatoma HepG2 cells (Lin et al. 2008).
Zinc oxide nanoparticles impeded proliferation by 50% after 20 μg/mL in comparison to media only treated or control cells, which correlates with our cellular viability and other studies which evaluated the toxicity of ZnO ENP exposures.
Interestingly, although n-HA impeded proliferation during the culture period (days 1, 4 and 7), the cell functionality such as alkaline phosphatase (ALP) and protein expressions were ameliorated on mineralized nanofibers.
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Teng, T., Mercer, C. A., Hexley, P., Thomas, G. & Fumagalli, S. Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.
These cytoskeletal proteins have been shown to impede proliferation when ectopically expressed [4], [5], [6].
Indeed, the differentiate cytoskeleton formed by keratins K1 and 10 has been shown to impede proliferation both in vitro and in vivo [4], [5], [6].
Cells co-expressing cyclin E and/or A and keratins 1 or 10 must be in cycle in the absence of cell division (endoreplication), since these cytoskeletal proteins have been shown to impede proliferation in vitro and in vivo [4], [5], [6].
Hereby, transfection of dsP21-397 causes BC cells' cycle arrest and impedes proliferation.
Likewise, miR-200c and miR-141 directly inhibited JAGGED1, impeding proliferation of human metastatic prostate cancer cells.
Taking the results together, we conclude that PI deficiency impedes proliferation and induces apoptosis of IECs, causing villous atrophy and intestinal hypoplasia.
Let-7a is a well-characterised tumour suppressor miRNA and has been shown to impede proliferation in cancer cell lines, and hence, was used as a positive control in this experiment.
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