Sentence examples for impede the binding from inspiring English sources

Epigenetic marks can cooperatively regulate chromatin accessibility and in turn facilitate or impede the binding of regulatory factors to various elements, suggesting their important roles in regulatory circuits.

This is usually due to point mutations in the BCR-ABL ATP-binding site, that impede the binding of imatinib [11].

H3R2me2 has been found to impede the binding of effector proteins to H3K4me3 and thus to control gene expression [ 28].

A challenge that must be met is the fact that Gram-negative bacteria possess very large pools of GSH that could impede the binding of any potential drug.

The increase of MEL-A probably enhances the density of an ordered conformation needed for the interaction with HIgG; this finally might impede the binding of HSA.

Methylation in CpG-rich regions within gene promoters is commonly associated with repressed gene expression, because it may impede the binding of transcription factors (Hashimshony et al. 2003).

-Zuonin A also binds JNK but barely impedes the binding of c-Jun.

If true, then it could be predicted that self-compatible S-pollen protein should bind the active pocket region, thus impeding the binding of the general inhibitor.

Soluble VEGFR2 fragments can bind endogenous VEGF, thereby blocking the action of VEGF and impeding the binding of VEGFR1, VEGFR2, and VEGFR3 to cell membrane ligands, inhibiting the VEGF-induced signaling pathway, and preventing angiogenesis [ 8].

The natural inhibitor of the IAPs is the protein Smac, which impedes the binding to the caspases.

The authors of the previous reports proposed that steric hindrance is one of major factors that impedes the binding of 5-substituted C in the hAID catalytic pocket39.