Sentence examples for impede cell cycle progression from inspiring English sources
Cell-cycle arrest persisted 96 h after nutlin-3a incubation (Figure 2A), suggesting that nutlin-3a might impede cell cycle progression at both the G1/S and G2/M checkpoints in wild-type p53 U87MG cell line.
Since neither of these key tumor suppressors impede cell cycle progression in Lmna−/− cells, it is more likely that mutations inactivating A-type lamin function also contribute to tumorigenesis.
However, our array analysis also predicted the unexpected finding that T. cruzi infection might impede cell cycle progression, on the basis that the top GO terms associated with downregulated cytokine-independent genes in HFF and HMVEC were associated with mitosis and cell division.
Salubrinal thus appeared to be non-toxic for K562 CML cells, but slightly impeded cell cycle progression and synergistically enhanced the cytotoxicity of the proteasome inhibitor PSI.
Furthermore, the overall dampening of host cell genes related to the mitotic cell cycle and cell division, suggested that T. cruzi infection impedes cell cycle progression in the host cell.
The finding of this work is in agreement with previous work showing that deletion of the c-myc gene impedes cell cycle progression thus retarding cell proliferation [ 23, 24].
It is well documented that E2F-1 possesses an intrinsic nuclear localization signal whereas E2F-4 is devoid of such signal [ 49, 50], and that the mechanism of E2F-4 nuclocalizationation has been documented to be through its interaction with Rb2/p130 pocket protein, which impedes cell cycle progression [ 39, 40].
A number of transcriptional repressors of CDH1 have been demonstrated to impede cell-cycle progression directly (reviewed in [ 22]).
Thus PRAP1 expression may be induced by non-DNA-damaging cellular stresses, possibly to impede cell-cycle progression.
In addition, the downregulation of genes involved in mitotic cell cycle and cell division predicted that T. cruzi infection may impede host cell cycle progression.
Whereas GUT-70 impeded G1-S cell cycle progression in JVM-2 and Granta 519 cells, G1-S arrest was minimal in MINO and Jeko-1 cells.
