The merocyanine form is highly polarized and imparts changes in solubility, opens up chelation possibilities, and can cause aggregation of dye molecules in non-polar environments.
The introduction of equivalent constructs within the heteromeric receptor imparts changes in conductance, agonist potency and cooperativity, further supporting an involvement of the ICD in allosteric communication between the portal region and critical residues in the TMD and/or ECD of the 5-HT3A receptor.
Specifically, fibers in NNW scaffolds are effectively stiffer than if acting alone due to extensive fiber-fiber cross-over points that impart changes in fiber geometry, particularly crimp wavelength and amplitude.
Microstructural aggregation and morphology of surfactant micelles impart changes in macroscopic behavior and flow properties of the surfactant solution under certain conditions (Gaudino et al. 2015; Schramm 2000; Trickett and Eastoe 2008; van Zanten 2011).
For example, R-loops would impart changes in local nucleosome organization and alter the sensitivity of DNA within chromatin to nucleases, which is a hallmark of most recombination hotspots and is invoked as a feature of most current models.
These mutations affect the reduction potential in two ways: by altering the interaction mode with quinone, which is known to affect the reduction potential, and by altering the positioning of the [2Fe−2S]-containing domain of the Rieske protein, which can impart changes in both the reduction potential and the EPR signal shape.
In addition, overnutrition and obesity impart significant changes in the architecture of adipose tissue that are strongly associated with metabolic dysfunction.
Substitutions at residue M250 within LVDr HBV that result in ETVr are less straightforward to interpret and suggest resistance may be imparted by changes in both the dNTP binding site and in the position of the growing DNA chain.
The PrPsc template is necessary to promote conversion of PrPc in transmitted disease, but mutations in the PrP gene can impart intrinsic changes in PrPc primary structure that fosters spontaneous conformational conversion that leads to abnormal protein aggregation and prion diseases [1], [16].
This is likely a reflection of differences in microbial community profiles, which are specific to each location, and imparted from changes in physicochemical conditions [16], [26], [30], [31], [32], [33].
The PiIEF test, also known as AAT phenotyping test, is based on the principle that mutations in the AAT gene (SERPINA1) will impart changes to the isoelectric point of the AAT protein.
