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It is likely that a combination of targeting dendritic cells to stimulate antitumor immunity and tumor-associated macrophages to reduce immune suppression will impart significant benefits and result in durable antitumor responses.
Oysters impart significant socio-ecological benefits from primary production of food supply, to estuarine ecosystems via reduction of water column nutrients, plankton and seston biomass.
We acknowledge that the activity of DES may be modestly higher when it is combined with D, which has been shown to have single-agent anti-tumour activity in men with castration-resistant prostate cancer, although there is little evidence that this therapeutic manoeuvre imparts significant clinical benefit (Venkitaraman et al, 2008).
Therefore, combined with the established benefits of appropriate d-transition metals, or as homometallic species, lanthanide-based compounds impart significant structural and magnetic properties, distinct from their 3d cousins, giving some of the best performing SMMs and magnetic refrigerants.
However, decavanadates did not impart significant corrosion protection.
Today PP fibres might be able to impart significant toughness and ductility to concrete.
These post-operative infections impart significant additional morbidity.
Such modifications are believed to impart significant functional changes to the miRNA.
Switching of an ARDS patient from VCV to HFOV does not impart significant hemodynamic instabilities and can be safely done.
This will help to ensure that potentially valuable agents are not discarded because of the inefficacy of a single agent, when these agents could impart clinically significant benefit when used in combination.
In the university sector it has long been recognised that the completion of an undergraduate degree imparts significant social and economic benefits on students and society as a whole (Borland 2002; James 2001; Marks 2007).
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